Protein Details: Potassium voltage-gated channel subfamily E member 4

Protein ID

ICDB_Pro_1343

Protein Name

Potassium voltage-gated channel subfamily E member 4

Gene Name

KCNE4

Organism

Homo sapiens (Human)

Length

221 amino acids

AlphaFoldDB

AF-Q8WWG9-F1-model_v4.pdb

Function

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 and inhibits potassium currents

Sequence

MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLAPAVEAASMLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADDELEETSETPLNESSEGSSENIHQNS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Arrhythmogenic Right Ventricular Dysplasia;Familial;5 and Atrial Fibrillation

Location

Predominantly expressed in embryo and adult uterus. Low expression found in kidney; small intestine; lung and heart.

DOI ID

10.1038/ng1285; 10.1038/nature03466; 10.1101/gr.2596504; 10.1113/jphysiol.2002.017301; 10.1085/jgp.200910234; 10.1002/jcp.22265; 10.1096/fj.201600467r

RefSeq

NP_542402.3